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Key Clinical Message  Bone marrow involvement by an isolated interstitial lymphoid aggregate exhibiting the pattern and phenotype described for follicular lymphoma in situ ( FLIS ) has not been reported before. The detection of clinically silent  FL  in this case highlights the necessity of complete staging workup when such lesions are encountered in biopsies.

Follicular lymphoma (in situ) pattern in the bone marrow: does it indicate an early stage in disease evolution?