Open AccessA novel mutation of SETBP 1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia
Author(s) -
Hu WangQiang,
Wang XiaoXia,
Yang RongRong,
Xie YaoSheng,
Zhang Zhuo,
Lu Hong,
Wu LianFeng,
Lai MeiMei,
Yu Kang
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.243
Subject(s) - chronic myelomonocytic leukemia , medicine , mutation , myeloid leukemia , leukemia , cancer research , acute myelomonocytic leukemia , mutation testing , myeloid , immunology , genetics , biology , gene , bone marrow , myelodysplastic syndromes
Key Clinical Message To investigate an oncogenic mutation of SETBP 1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML . Clinical data and molecular studies were analyzed of paired aCML and 'normal' DNA from a case with M4. We identified a mutation in SETBP 1 (encoding a p.Asp868Ala alteration). The analysis of paired sample indicated that SETBP 1 mutation was acquired during leukemic evolution.