Open AccessTendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications
Author(s) -
Cano Cevallos Edison Jose,
Shaikh Danial Haris,
Gonzalez Jose,
Sanchez William,
Patel Madanmohan
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2387
Subject(s) - medicine , gemfibrozil , simvastatin , statin , concomitant , achilles tendon , tendon , achilles tendon rupture , atorvastatin , intensive care medicine , surgery , cholesterol
Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co‐administration of statin and gemfibrozil should warrant prescribers’ awareness of tendon‐related complications of statin use, particularly in high‐risk populations with poor renal function or musculoskeletal comorbidities.