Open AccessAmplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
Author(s) -
Katagiri Katsunori,
Shiga Kiyoto,
Saito Daisuke,
Oikawa Shinichi,
Ikeda Aya,
Tsuchida Kodai,
Miyaguchi Jun
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2349
Subject(s) - nivolumab , medicine , melanoma , glucocorticoid , antibody , prednisolone , cancer research , effector , lung , oncology , immunology , immunotherapy , cancer
Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.