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Key Clinical Message  A 65‐year‐old male, Parkinson's disease patient, was evaluated for  GPR 109A expression, niacin index,  UPDRS  scale, handwriting test, and quality of sleep with and without niacin treatment. The evaluation was repeated 3 months after niacin was stopped. Niacin modulated the abovementioned parameters and showed the overall improvement without side effects.

Low‐dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects