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Key Clinical Message  t(11;17) is a rare but recognized finding usually found in Acute Promyelocytic Leukemia with variant  RARA  translocation (APLv). We present a case of Acute Myeloid Leukemia with t(11;17) that has different break points than those occurring in APLv. The diagnosis of acute myeloid leukemia, not otherwise specified, acute monoblastic leukemia was reached after a thorough investigation. Reaching the correct diagnosis and distinguishing these two entities are essential as they have different management, prognosis, and overall survival.

Non‐acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17)