Open AccessFinding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia
Author(s) -
Fetzko Stephanie,
Ahmed Asra,
Cooling Laura
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.203
Subject(s) - medicine , autoimmune hemolytic anemia , autoantibody , splenectomy , immunology , coombs test , hemolytic anemia , anemia , antibody , spleen
Key Clinical Message An isolated IgA‐mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test ( DAT ) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG‐mediated WAIHA , steroids are first‐line treatment, though splenectomy is often required to achieve a durable treatment response.