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Key Clinical Message  An isolated IgA‐mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test ( DAT ) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG‐mediated  WAIHA , steroids are first‐line treatment, though splenectomy is often required to achieve a durable treatment response.

Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia