Open AccessA child with Klinefelter syndrome and both IgE‐mediated food allergy and low proportion of naive Treg
Author(s) -
Frederick Rachel,
Vuillermin Peter,
Tang Mimi L. K.,
Ponsonby AnneLouise,
Webster Elise,
Saffery Richard,
Collier Fiona
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1928
Subject(s) - medicine , foxp3 , immunology , immunoglobulin e , immune system , allergy , treg cell , food allergy , klinefelter syndrome , il 2 receptor , antibody , t cell
Key Clinical Message This case suggests a possible association between Klinefelter Syndrome and decreased regulatory T cells (Treg) cells, relating to an increased risk of allergic and autoimmune disorders in these patients. The immune phenotyping of the circulating FOXP3+ naive Treg populations in KS patients may help to indicate this predisposition.