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Key Clinical Message  We report here an intrasplenic large mass in an elderly case of essential thrombocythemia (ET)‐myelofibrosis. Laparoscopic splenectomy revealed extramedullary hematopoiesis (EMH) and a type 1  CALR  gene mutation (CALR‐c.1092_1143del52) in the splenic mass. It remains to be determined if  CALR‐ mutated ET has an increased tendency to develop mass‐forming EMH.

Splenic mass in a case of CALR ‐mutated essential thrombocythemia