Open AccessSplenic mass in a case of CALR ‐mutated essential thrombocythemia
Author(s) -
Imashuku Shinsaku,
Kotani Shinichi,
Hinami Junsuke,
Nishimura Keisuke
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1857
Subject(s) - medicine , essential thrombocythemia , calreticulin , myelofibrosis , polycythemia vera , genetics , bone marrow , endoplasmic reticulum , biology
Key Clinical Message We report here an intrasplenic large mass in an elderly case of essential thrombocythemia (ET)‐myelofibrosis. Laparoscopic splenectomy revealed extramedullary hematopoiesis (EMH) and a type 1 CALR gene mutation (CALR‐c.1092_1143del52) in the splenic mass. It remains to be determined if CALR‐ mutated ET has an increased tendency to develop mass‐forming EMH.