Open AccessNeonatal acute megakaryoblastic leukemia mimicking congenital neuroblastoma
Author(s) -
Kawasaki Yukako,
Makimoto Masami,
Nomura Keiko,
Hoshino Akihiro,
Hamashima Takeru,
Hiwatari Mitsuteru,
Nakazawa Atsuko,
Takita Junko,
Yoshida Taketoshi,
Kanegane Hirokazu
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.183
Subject(s) - medicine , acute megakaryoblastic leukemia , neuroblastoma , abdominal distension , autopsy , enolase , leukemia , pathology , immunohistochemistry , biology , genetics , cell culture
Key Clinical Message We describe a neonate with abdominal distension, massive hepatomegaly, and high serum neuron‐specific enolase level suggestive of congenital neuroblastoma. The patient died of pulmonary hemorrhage after therapy. Autopsy revealed that the tumor cells in the liver indicated acute megakaryocytic leukemia with the RBM 15‐ MKL 1 fusion gene.