Open AccessRefractory immune thrombocytopenia. Successful treatment with repeated cyclosporine A: two case reports
Author(s) -
Hlusi Antonin,
Szotkowski Tomas,
Indrak Karel
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.182
Subject(s) - medicine , splenectomy , refractory (planetary science) , immune thrombocytopenia , immunosuppression , platelet , ciclosporin , surgery , gastroenterology , chemotherapy , spleen , physics , astrobiology
Key Clinical Message Treatment of chronic, severe refractory immune thrombocytopenia after splenectomy is difficult. Only less data exist on clinical use of cyclosporine A (CyA) in the management of refractory ITP . In this report, we describe two cases in which standard immunosuppressive therapy, other immunosuppression including cyclosporine A or splenectomy had no therapeutic effect. Even after splenectomy, recommended procedures were inefficient and critical thrombocytes count persisted. After repeated administration of cyclosporine A which had been ineffective prior to splenectomy; however, both patients achieved long‐term complete remission of the ITP . Side effects of CyA were moderate. The presented cases have confirmed the potential therapeutic effect of CyA in refractory post‐ SE ITP .