Open AccessFulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
Author(s) -
Singh Zeba N.,
Jethava Yogesh,
Post Ginell R.,
Alapat Daisy,
Sawyer Jeffrey,
Waheed Sarah,
Nair Bijay,
Usmani Saad Z.,
Bailey Clyde,
Petty Nathan,
Van Rhee Frits,
Barlogie Bart
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.180
Subject(s) - medicine , multiple myeloma , fulminant , haematopoiesis , acute leukemia , leukemia , oncology , gastroenterology , pediatrics , stem cell , genetics , biology
Key Clinical Message Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy‐related myeloid neoplasms (t‐ MN ). Current modalities include metaphase cytogenetics and FISH . Since t‐ MN may develop abruptly in cytogenetically normal patients, a discussion exploring additional methods such as SNP ‐array and targeted‐deep‐sequencing to detect subchromosomal abnormalities is needed.