Open AccessDisseminated histoplasmosis associated with acquired hemophagocytic lymphohistiocytosis
Author(s) -
Rajput Ashish,
BenceBruckler Isabelle,
Huebsch Lothar,
Jessamine Peter,
Toye Baldwin,
Padmore Ruth
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.179
Subject(s) - hemophagocytic lymphohistiocytosis , medicine , histiocyte , histiocytosis , immunology , macrophage activation syndrome , histoplasmosis , disease , pathology , arthritis
Key Clinical Message Hemophagocytic lymphohistiocytosis (HLH) is a potentially life‐threatening clinical syndrome caused by uncontrolled activation of lymphocytes and histiocytes resulting in high levels of cytokines. Acquired HLH occurs in autoimmune, inflammatory, infectious, and immunosuppressive disorders. Prompt identification and treatment of an underlying triggering cause improves clinical outcome.