Open AccessPreoperative administration of eculizumab to prevent surgery‐triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria
Author(s) -
Li Dongping,
Wang Liangcheng,
Horiuchi Isao,
Kimura Shunichi,
Chikazawa Kenro,
Kimura Azusa,
Sasaki Shigetane,
Kuwata Tomoyuki,
Takagi Kenjiro
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1707
Subject(s) - paroxysmal nocturnal hemoglobinuria , eculizumab , medicine , hemoglobinuria , hemolysis , pregnancy , cesarean delivery , anesthesia , preeclampsia , surgery , complement system , immunology , antibody , biology , genetics
Key Clinical message Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery‐triggered hemolysis. An additional dose of eculizumab just prior to delivery is an appropriate choice to prevent postoperative hemolysis.