Open AccessCo‐occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death
Author(s) -
Tamura Akihiro,
Uemura Suguru,
Matsubara Kousaku,
Kozuki Eru,
Tanaka Toshikatsu,
Nino Nanako,
Yokoi Takehito,
Saito Atsuro,
Ishida Toshiaki,
Hasegawa Daiichiro,
Umeki Ikumi,
Niihori Tetsuya,
Nakazawa Yozo,
Koike Kenichi,
Aoki Yoko,
Kosaka Yoshiyuki
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1568
Subject(s) - noonan syndrome , medicine , juvenile myelomonocytic leukemia , hypertrophic cardiomyopathy , juvenile , cardiomyopathy , ptpn11 , pediatrics , cardiology , heart failure , cancer , genetics , colorectal cancer , stem cell , haematopoiesis , biology , kras
Key Clinical Message We report a case of a neonate with Noonan syndrome presenting with concurrent hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia, which resulted in premature death. Cases with Noonan syndrome diagnosed during the neonatal period might not necessarily show mild clinical course, and premature death is a possible outcome to be considered.