Open AccessFever in a transplant recipient: think beyond infection
Author(s) -
Kamboj Mayanka,
Chornyy Volodymyr,
Koratala Abhilash,
Santos Alfonso H.
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1432
Subject(s) - immune reconstitution inflammatory syndrome , medicine , immune system , calcineurin , immunology , sepsis , tuberculosis , inflammation , intensive care medicine , transplantation , pathology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
Key Clinical Message Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated inflammatory cascade initiated in response to immune recovery during the resolution of an infection. Reduction in calcineurin inhibitor levels in organ transplant recipients due to enhanced metabolism from interaction with rifampin can predispose these individuals to develop IRIS during the treatment of tuberculosis and mimic sepsis.