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Key Clinical Message  A Japanese boy aged 7 years with Bainbridge‐Ropers syndrome ( BRPS ) had a prominent domed forehead without metric ridge, mild prominence of the Sylvian fissure with bitemporal hollowing, and a heterozygous de novo novel variant “p.P1010Lfs*14” in   ASXL 3  gene in addition to typical findings of  BRPS .

Mild prominence of the Sylvian fissure in a Bainbridge‐Ropers syndrome patient with a novel frameshift variant in ASXL 3