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Key Clinical Message  Methotrexate‐induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke‐like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be  IV  or intrathecal and still results in leukoencephalopathy.

Methotrexate‐induced leukoencephalopathy presenting as stroke in the emergency department