Open AccessNatural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
Author(s) -
Xiang Zhifu,
Kaur Varinder,
Aburiziq Ibrahim K.,
Mehta Paulette,
Emanuel Peter,
Schichman Steven A.
Publication year - 2014
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.110
Subject(s) - chronic myelomonocytic leukemia , medicine , myeloid leukemia , natural history , gene , acute myelomonocytic leukemia , leukemia , myeloid , somatic evolution in cancer , immunology , cancer research , genetics , cancer , bone marrow , myelodysplastic syndromes , biology
Key Clinical Message Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.