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The relationship between re‐endothelialization and endothelial function after DES implantation: Comparison between paclitaxcel eluting stent and zotarolims eluting stent
Author(s) -
Murase Suguru,
Suzuki Yoriyasu,
Yamaguchi Toshikazu,
Matsuda Osamu,
Murata Akira,
Ito Tatsuya
Publication year - 2013
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.25140
Subject(s) - medicine , stent , cardiology , drug eluting stent , vasoconstriction , coronary arteries , endothelial dysfunction , restenosis , artery
Background Several studies have reported re‐endothelialization and endothelial function after drug‐eluting stent (DES) implantation; however, the relationship between re‐endothelialization and endothelial function after DES implantation has not been investigated yet. Methods A total of 14 patients underwent evaluation of re‐endothelialization by optical coherence tomography (OCT) and endothelial function by incremental Ach infusion at 9 months after DES implantation (ZES: N = 7, PES: N = 7). The neointimal thickness (NIT) inside each strut, strut coverage, and malapposition at every 1 mm cross‐section were evaluated by OCT and the endothelial function was estimated by measuring the coronary vaso‐reactivity in response to acetylcholine (Ach) infusion into coronary arteries. Results Zotarolims eluting stent (ZES), compared with paclitaxcel eluting stent (PES), showed more homogeneous neointimal coverage of stent struts and low rate of malapposition. Vasoconstriction in response to Ach in the peri‐stent region was also less pronounced in ZES than PES. In particular, vasoconstriction was more often observed in cases with inhomogeneous neointimal coverage of stent struts in the PES group. Conclusions Our findings suggest that endothelial function seems to be better preserved with ZES than PES, and homogeneous neointimal coverage of stent struts seem to be associated with the preserved endothelial function. © 2013 Wiley Periodicals, Inc.