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Synthetic and Crystallographic Insight into Exploiting sp 2 Hybridization in the Development of α‐ l ‐Fucosidase Inhibitors
Author(s) -
Coyle Travis,
Wu Liang,
Debowski Aleksandra W.,
Davies Gideon J.,
Stubbs Keith A.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800710
Subject(s) - fucosidase , fucose , glycoconjugate , enzyme , biochemistry , stereochemistry , chemistry , glycan , biology , glycoprotein
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α‐ l ‐fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α‐ l ‐fucosidase inhibitors, with X‐ray crystallographic analysis using an α‐ l ‐fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.