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Dynamic, Electrostatic Model for the Generation and Control of High‐Energy Radical Intermediates by a Coenzyme B 12 ‐Dependent Enzyme
Author(s) -
Chen ZhiGang,
Ziętek Monika A,
Russell Henry J.,
Tait Shirley,
Hay Sam,
Jones Alex R.,
Scrutton Nigel S.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300420
Subject(s) - radical , chemistry , homolysis , enzyme catalysis , photochemistry , stereochemistry , enzyme , organic chemistry
Radical control: A single glutamate residue (E287) in the coenzyme B 12 ‐dependent ethanolamine ammonia lyase is pivotal to generating high‐energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions.