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DNA Labeling by Ligand Inducible Secondary Structure
Author(s) -
Peng Tao,
He Hanping,
Hagihara Masaki,
Nakatani Kazuhiko
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800254
Subject(s) - typing , snp , single nucleotide polymorphism , computational biology , dna , personalized medicine , computer science , ligand (biochemistry) , genetics , chemistry , biology , gene , genotype , receptor
Personalized medical solutions : Simple, accurate, and cost effective methods of single nucleotide polymorphism typing would be necessary for personalized medicine. Towards this end, a number of SNP typing methods have been investigated and reported. We report herein, our chemical approach to practical SNP typing based on allele‐specific PCR integrated with a new concept of DNA‐labeling by ligand‐inducible secondary structure.