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Nucleoside syntheses, XXV 1) A new simplified nucleoside synthesis
Author(s) -
Vorbrüggen Helmut,
Bennua Bärbel
Publication year - 1981
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19811140407
Subject(s) - chemistry , silylation , nucleoside , catalysis , organic chemistry , combinatorial chemistry , stereochemistry
The several steps of the Friedel‐Crafts catalyzed silyl‐Hilbert‐Johnson nucleoside synthesis ‐ silylation of the heterocyclic base, silylation of the perfluorosulfonic acids or its salts (if SnCl 4 is not used as catalyst) and finally the nucleoside synthesis itself ‐ can be combined to a simple one‐step/one‐pot reaction which generally affords nucleosides in high yields.
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