Open AccessIdentification of immune‐activating metabolite for enhancing T cell therapy of cancer
Author(s) -
Cong Boyi,
Cui Zenghui,
Cao Xuetao
Publication year - 2021
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1002/cac2.12177
Subject(s) - t cell , effector , immunotherapy , immune system , cancer immunotherapy , cd8 , computational biology , biology , metabolite , cancer research , t cell receptor , cancer , function (biology) , microbiology and biotechnology , biochemistry , immunology , genetics
In this Research Highlight, we summarized the results from a study by Wu et al . published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8 + T cells towards tumour through lymphocyte‐specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy.