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Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC‐fluorescence method
Author(s) -
Hassan Mohamed G.,
Ikeda Rie,
Wada Mitsuhiro,
Kuroda Naotaka,
AbdelWadood Hanaa M.,
Mohamed Horria A.,
Nakashima Kenichiro
Publication year - 2013
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.2980
Subject(s) - chemistry , pharmacokinetics , chromatography , high performance liquid chromatography , memantine , fluorescence , plasma concentration , plasma , pharmacology , biochemistry , receptor , nmda receptor , medicine , physics , quantum mechanics
ABSTRACT The present study aims to investigate the possibility of interaction of donepezil (DP) and galantamine (GAL) as acetylcholinestrase inhibitors, on memantine (MT) hydrochloride in rat plasma by HPLC‐fluorescence detection. The separation of MT was achieved within 12 min without interference of DP and GAL on the chromatogram. MT levels in rat plasma with a single administration of MT (2.5 mg/kg, i.p.) and those with a co‐administration of DP (5.0 mg/kg, i.p.) and GAL (3 mg/kg, i.p.) were monitored. MT concentrations determined in rat plasma ranged from 10.0 to 245.6 ng/mL. Significant difference was observed in the behavior of MT with a co‐administration of DP, while no significant difference was observed with a co‐administration of GAL. Copyright © 2013 John Wiley & Sons, Ltd.