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Undergraduate biochemistry laboratory courses often do not provide studentswith an authentic research experience, particularly when the express purpose ofthe laboratory is purely instructional. However, an instructional laboratorycourse that is inquiry- and research-based could simultaneously impartscientific knowledge and foster a student's research expertise and confidence.We have developed a year-long undergraduate biochemistry laboratory curriculumwherein students determine, via experiment and computation, the function of aprotein of known three-dimensional structure. The first half of the course isinquiry-based and modular in design; students learn general biochemicaltechniques while gaining preparation for research experiments in the secondsemester. Having learned standard biochemical methods in the first semester,students independently pursue their own (original) research projects in thesecond semester. This new curriculum has yielded an improvement in studentperformance and confidence as assessed by various metrics. To disseminateteaching resources to students and instructors alike, a freely accessibleBiochemistry Laboratory Education resource is available athttp://biochemlab.org.

Known structure, unknown function: An inquiry‐based undergraduate biochemistry laboratory course