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Background  Society of Surgical Oncology and American Society for Radiation Oncology guidelines define clear margins in breast‐conserving therapy (BCT) as ‘no ink on tumour’, in contrast to the attainment of margins of at least 1 mm widely practised in the UK. The primary aim of this study was to explore clinical, surgical and tumour‐related factors associated with local recurrence after BCT, with a secondary aim of assessing the impact of margin re‐excision on the risk of local recurrence.    Methods  Patient demographics, surgical details, tumour characteristics and local recurrence were recorded for consecutive women with BCT undergoing surgery between January 1997 and January 2007. Margins were defined as clear (greater than 1 mm), close (less than 1 mm but no ink on tumour), reaches (ink on tumour) and clear after re‐excision.    Results  A total of 1045 women of median age 54 (range 18–86) years were studied. Median follow‐up was 89 (range 4–196) months. Local recurrence occurred in 52 patients (5·0 per cent). Ink on tumour was associated with local recurrence (hazard ratio (HR) 4·86, 95 per cent c.i. 1·49 to 15·79;  P  = 0·009). Risk of local recurrence was the same for close and clear margins (HR 1·03, 0·40 to 2·62;  P  = 0·954). In women with involved margins, re‐excision was still associated with an increased local recurrence risk (HR 2·50, 1·32 to 4·72;  P  = 0·005). Oestrogen receptor negativity increased risk (HR 2·28, 1·28 to 4·06;  P  = 0·005).    Conclusion  Adequately excised margins, even when under 1 mm, provide equivalent outcomes to wider margins in BCT. Achieving complete excision at primary surgery achieves the lowest rates of local recurrence.

Complete excision with narrow margins provides equivalent local control to wider excision in breast conservation for invasive cancer