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Practical identifiability of growth and substrate consumption models
Author(s) -
Nihtilä Markku,
Virkkunen Jouko
Publication year - 1977
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260191208
Subject(s) - identifiability , substrate (aquarium) , trichoderma viride , biological system , estimation theory , consumption (sociology) , mathematics , differential (mechanical device) , econometrics , mathematical optimization , chemistry , statistics , thermodynamics , physics , ecology , biology , food science , social science , sociology
Abstract The estimation of parameters in several dynamic models, which describe growth and substrate consumption, has been carried out using a modified Gauss–Newton‐type method. The four models considered are Monod, Contois, linear specific growth rate, and an enzyme kinetic model. The initial values of the differential equations are included in the parameter vector which will be estimated. The efficiency of the method and the confidence limits of the parameters were studied using simulated measurement noise. The experimental results describe Trichoderma viride growing on glucose as the main carbon source.