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Novel insights on interactions between folate and lipid metabolism
Author(s) -
Silva Robin P.,
Kelly Karen B.,
Al Rajabi Ala,
Jacobs René L.
Publication year - 2013
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1154
Subject(s) - steatohepatitis , methylation , lipid metabolism , dna methylation , carnitine , fatty liver , choline , phosphatidylcholine , biochemistry , creatine , biology , metabolism , chemistry , medicine , phospholipid , disease , gene expression , gene , membrane
Folate is an essential B vitamin required for the maintenance of AdoMet‐dependent methylation. The liver is responsible for many methylation reactions that are used for post‐translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non‐alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid‐related folate research. © 2013 BioFactors, 40(3):277–283, 2014