Premium
BioEssays S1/2016
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201670899
Subject(s) - citation , computer science , cover (algebra) , computational biology , genome , information retrieval , stella (programming language) , world wide web , genetics , biology , artificial intelligence , gene , engineering , mechanical engineering
One of the main questions in the use of genome editing tools is their specificity and the degree of possible off‐target events. The cover shows two of the protein scaffolds commonly used for this purpose, TALE and Cas9, targeting a DNA site for the generation of specific cleavage. As discussed by Stella and Montoya in this issue, a key element in this genome modification strategy is whether DNA binding has been achieved accurately to generate the desired modification in the right genomic site.