BioEssays S1/2016

One of the main questions in the use of genome editing tools is their specificity and the degree of possible off‐target events. The cover shows two of the protein scaffolds commonly used for this purpose, TALE and Cas9, targeting a DNA site for the generation of specific cleavage. As discussed by Stella and Montoya in this issue, a key element in this genome modification strategy is whether DNA binding has been achieved accurately to generate the desired modification in the right genomic site.