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Small GTPases in the Rho family act as major nodes with functions beyond cytoskeletal rearrangements shaping the  Caenorhabditis elegans  embryo during development. These small GTPases are key signal transducers that integrate diverse developmental signals to produce a coordinated response in the cell. In  C. elegans,  the best studied members of these highly conserved Rho family small GTPases, RHO‐1/RhoA, CED‐10/Rac, and CDC‐42, are crucial in several cellular processes dealing with cytoskeletal reorganization. In this review, we update the functions described for the Rho family small GTPases in spindle orientation and cell division, engulfment, and cellular movements during  C. elegans  embryogenesis, focusing on the Rho subfamily Rac.  Please also see the video abstract  here

Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated