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A robust treatment of a dose–response study
Author(s) -
Wiens Douglas P.,
Li Pengfei
Publication year - 2011
Publication title -
applied stochastic models in business and industry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 40
eISSN - 1526-4025
pISSN - 1524-1904
DOI - 10.1002/asmb.917
Subject(s) - robustification , flexibility (engineering) , link (geometry) , function (biology) , range (aeronautics) , computer science , econometrics , mathematical optimization , mathematics , statistics , engineering , combinatorics , evolutionary biology , biology , aerospace engineering , outlier
We give a description of the steps leading to a robustification of a dose–response study. The original experiment was designed and described by Rosenberger and Grill (1997) and has since been discussed by several other groups of researchers. Our robustification consists of redesigning the experiment so as to build in flexibility over a range of possible link functions, including the logistic link assumed by the original experimenters. We consider as well an asymptotic Neyman–Pearson test of the validity of the assumed link function.Copyright © 2011 John Wiley & Sons, Ltd.