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The photoinitiated thiol−ene addition reaction is a highly stereo‐ and regioselective, and environmentally friendly reaction proceeding under mild conditions, hence it is ideally suited for the synthesis of carbohydrate mimetics. A comprehensive study on UV‐light‐induced reactions of 2,3‐unsaturated  O ‐,  C ‐,  S ‐ and  N ‐glycosides with various thiols was performed. The effect of experimental parameters and structural variations of the alkenes and thiols on the efficacy and regio‐ and stereoselectivity of the reactions was systematically studied and optimized. The type of anomeric heteroatom was found to profoundly affect the reactivity of 2,3‐unsaturated sugars in the thiol−ene couplings. Hydrothiolation of 2,3‐dideoxy  O ‐glycosyl enosides efficiently produced the axially C2‐ S ‐substituted addition products with high to complete regioselectivity. Moderate efficacy and varying regio‐ and stereoselectivity were observed with 2,3‐unsaturated  N ‐glycosides and no addition occurred onto the endocyclic double bond of  C ‐glycosides. Upon hydrothiolation of 2,3‐unsaturated  S ‐glycosides, the addition of thiyl radicals was followed by elimination of the thiyl aglycone resulting in 3‐ S ‐substituted glycals.

Photoinitiated Thiol−Ene Reactions of Various 2,3‐Unsaturated O ‐, C ‐ S ‐ and N ‐Glycosides – Scope and Limitations Study