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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Author(s) -
Destro Gianluca,
Horkka Kaisa,
Loreau Olivier,
Buisson DavidAlexandre,
Kingston Lee,
Del Vecchio Antonio,
Schou Magnus,
Elmore Charles S.,
Taran Frédéric,
Cantat Thibault,
Audisio Davide
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002341
Subject(s) - acetic acid , isotopes of carbon , carbon fibers , chemistry , transition metal , isotope , carbon 14 , metal , inorganic chemistry , organic chemistry , catalysis , materials science , total organic carbon , physics , quantum mechanics , composite number , composite material
A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO 2 , this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activity valuable for distribution studies.