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Insights into Cobalta(III/IV/II)‐Electrocatalysis: Oxidation‐Induced Reductive Elimination for Twofold C−H Activation
Author(s) -
Meyer Tjark H.,
Oliveira João C. A.,
Ghorai Debasish,
Ackermann Lutz
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002258
Subject(s) - electrocatalyst , cobalt , chemistry , electrosynthesis , electrochemistry , catalysis , combinatorial chemistry , redox , reactive intermediate , inorganic chemistry , organic chemistry , electrode
The merger of cobalt‐catalyzed C−H activation and electrosynthesis provides new avenues for resource‐economical molecular syntheses, unfortunately their reaction mechanisms remain poorly understood. Herein, we report the identification and full characterization of electrochemically generated high‐valent cobalt(III/IV) complexes as crucial intermediates in electrochemical cobalt‐catalyzed C−H oxygenations. Detailed mechanistic studies provided support for an oxidatively‐induced reductive elimination via highly‐reactive cobalt(IV) intermediates. These key insights set the stage for unprecedented cobaltaelectro two‐fold C−H/C−H activation.