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NHC‐Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines
Author(s) -
Valero Mégane,
Bouzouita Donia,
Palazzolo Alberto,
Atzrodt Jens,
Dugave Christophe,
Tricard Simon,
Feuillastre Sophie,
Pieters Grégory,
Chaudret Bruno,
Derdau Volker
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201914369
Subject(s) - iridium , catalysis , deuterium , hydrogen isotope , chemistry , hydrogen , nanoparticle , tritium , isotope , carbene , inorganic chemistry , combinatorial chemistry , photochemistry , radiochemistry , organic chemistry , materials science , nanotechnology , physics , quantum mechanics , nuclear physics
The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air‐stable and easy‐to‐handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorporation on anilines using D 2 or T 2 as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals.