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Described herein are two different methods for the synthesis of vinyl halides by a shuttle catalysis based iridium‐catalyzed transfer hydrohalogenation of unactivated alkynes. The use of 4‐chlorobutan‐2‐one or  tert ‐butyl halide as donors of hydrogen halides allows this transformation in the absence of corrosive reagents, such as hydrogen halides or acid chlorides, thus largely improving the functional‐group tolerance and safety profile of these reactions compared to the state‐of‐the‐art. This method has granted access to alkenyl halide compounds containing acid‐sensitive groups, such as tertiary alcohols, silyl ethers, and acetals. The synthetic value of those methodologies has been demonstrated by gram‐scale synthesis where low catalyst loading was achieved.

Iridium‐Catalyzed Hydrochlorination and Hydrobromination of Alkynes by Shuttle Catalysis