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Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex
Author(s) -
van Rixel Vincent H. S.,
Busemann Anja,
Wissingh Mathijs F.,
Hopkins Samantha L.,
Siewert Bianka,
van de Griend Corjan,
Siegler Maxime A.,
Marzo Tiziano,
Papi Francesco,
Ferraroni Marta,
Gratteri Paola,
Bazzicalupi Carla,
Messori Luigi,
Bonnet Sylvestre
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201814532
Subject(s) - platinum , dna , stacking , supramolecular chemistry , chemistry , hydrogen bond , crystallography , stereochemistry , adduct , crystal structure , molecule , biochemistry , catalysis , organic chemistry
Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5′‐d(CGTACG)‐3′ specifically into a 4WJ‐like motif. In the crystal structure of the 1 –CGTACG adduct, the distorted‐square‐planar platinum complex binds to the core of the 4WJ‐like motif through π–π stacking and hydrogen bonding, without forming any platinum–nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.