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Ion‐Selective Electrodes Based on Hydrophilic Ionophore‐Modified Nanopores
Author(s) -
Papp Soma,
Jágerszki Gyula,
Gyurcsányi Róbert E.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800954
Subject(s) - ionophore , nanopore , membrane , nanoporous , electrode , ion , peptide , ion channel , chemistry , combinatorial chemistry , inorganic chemistry , nanotechnology , materials science , organic chemistry , biochemistry , receptor
We report the synthesis and analytical application of the first Cu 2+ ‐selective synthetic ion channel based on peptide‐modified gold nanopores. A Cu 2+ ‐binding peptide motif (Gly‐Gly‐His) along with two additional functional thiol derivatives inferring cation‐permselectivity and hydrophobicity was self‐assembled on the surface of gold nanoporous membranes comprising of about 5 nm diameter pores. These membranes were used to construct ion‐selective electrodes (ISEs) with extraordinary Cu 2+ selectivities, approaching six orders of magnitude over certain ions. Since all constituents are immobilized to a supporting nanoporous membrane, their leaching, that is a ubiquitous problem of conventional ionophore‐based ISEs was effectively suppressed.