Premium
Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins
Author(s) -
Alonsode Castro Silvia,
Cortajarena Aitziber L.,
LópezGallego Fernando,
Salassa Luca
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800288
Subject(s) - ruthenium , flavoprotein , bioorthogonal chemistry , platinum , catalysis , chemistry , combinatorial chemistry , biochemistry , enzyme , click chemistry
Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for performing chemoselective transformations in complex biological environments. Herein, we report how FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and four flavoproteins act as unconventional photocatalysts capable of converting Pt IV and Ru II complexes into potentially toxic Pt II or Ru II −OH 2 species. In the presence of electron donors and low doses of visible light, the flavoproteins mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) catalytically activate Pt IV prodrugs with bioorthogonal selectivity. In the presence of NADH, NOX catalyzes Pt IV activation in the dark as well, indicating for the first time that flavoenzymes may contribute to initiating the activity of Pt IV chemotherapeutic agents.