Premium
Palladium/Copper Dual Catalysis for the Cross‐Coupling of Aryl(trialkyl)silanes with Aryl Bromides
Author(s) -
Komiyama Takeshi,
Minami Yasunori,
Furuya Yuki,
Hiyama Tamejiro
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201712081
Subject(s) - aryl , silanes , chemistry , palladium , organic chemistry , catalysis , polymer chemistry , combinatorial chemistry , silane , alkyl
Abstract Whereas aryl(trialkyl)silanes are considered to be ideal organometallic reagents for cross‐coupling reactions owing to their stability, low toxicity, solubility, and easy accessibility, they are generally inert under typical cross‐coupling conditions. Disclosed herein is a palladium/copper catalytic system that enables the cross‐coupling of trimethyl, triethyl, tert‐butyldimethyl, and triisopropyl aryl silanes with aryl bromides. This process is applicable to the sequential C−H and C−Si bond arylation of thiophenes and the synthesis of poly(thiophene–fluorene)s.