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An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization
Author(s) -
FolgueirasAmador Ana A.,
Philipps Kai,
Guilbaud Sébastien,
Poelakker Jarno,
Wirth Thomas
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201709717
Subject(s) - microreactor , flow chemistry , electrochemistry , chemistry , surface modification , flow (mathematics) , combinatorial chemistry , process (computing) , intramolecular force , computer science , organic chemistry , catalysis , electrode , geometry , mathematics , operating system
Abstract Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.