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Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies
Author(s) -
Huck Bayard R.,
Kötzner Lisa,
Urbahns Klaus
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707816
Subject(s) - blockade , medicine , oncology , small molecule , cancer therapy , cancer , clinical oncology , chemistry , biochemistry , receptor
Abstract Immuno‐oncology therapies have the potential to revolutionize the armamentarium of available cancer treatments. To further improve clinical response rates, researchers are looking for novel combination regimens, with checkpoint blockade being used as a backbone of the treatment. This Review highlights the significance of small molecules in this approach, which holds promise to provide increased benefit to cancer patients.