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Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification
Author(s) -
Qu Guangbo,
Liu Wei,
Zhao Yuetao,
Gao Jie,
Xia Tian,
Shi Jianbo,
Hu Ligang,
Zhou Wenhua,
Gao Jiejun,
Wang Huaiyu,
Luo Qian,
Zhou Qunfang,
Liu Sijin,
Yu XueFeng,
Jiang Guibin
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706228
Subject(s) - biocompatibility , black phosphorus , in vivo , cytotoxicity , nanotechnology , chemical modification , chemistry , ligand (biochemistry) , combinatorial chemistry , materials science , in vitro , biochemistry , receptor , biology , organic chemistry , microbiology and biotechnology , optoelectronics
Black phosphorus nanosheets (BPs) show great potential for various applications including biomedicine, thus their potential side effects and corresponding improvement strategy deserve investigation. Here, in vitro and in vivo biological effects of BPs with and without titanium sulfonate ligand (TiL 4 ) modification are investigated. Compared to bare BPs, BPs with TiL 4 modification (TiL 4 @BPs) can efficiently escape from macrophages uptake, and reduce cytotoxicity and proinflammation. The corresponding mechanisms are also discussed. These findings may not only guide the applications of BPs, but also propose an efficient strategy to further improve the biocompatibility of BPs.