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Iridium‐Catalyzed Asymmetric Hydrogenation of Benzo[ b ]thiophene 1,1‐Dioxides
Author(s) -
Tosatti Paolo,
Pfaltz Andreas
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701409
Subject(s) - iridium , benzothiophene , thiophene , asymmetric hydrogenation , catalysis , chemistry , phosphinite , enantioselective synthesis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Abstract An efficient iridium‐catalyzed asymmetric hydrogenation of substituted benzothiophene 1,1‐dioxides is described. The use of iridium complexes with chiral pyridyl phosphinite ligands provides access to highly enantiomerically enriched sulfones with substituents at the 2‐ and 3‐position. Sulfones of this type are of interest as core structures of agrochemicals and pharmaceuticals. Moreover, they can be further reduced to chiral 2,3‐dihydrobenzothiophenes.

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