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Diastereoselective Synthesis of Cyclopenta[ c ]furans by a Catalytic Multicomponent Reaction
Author(s) -
Pathipati Stalin R.,
van der Werf Angela,
Eriksson Lars,
Selander Nicklas
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606108
Subject(s) - furan , chemistry , catalysis , indium , combinatorial chemistry , organic chemistry
A diastereoselective three‐component reaction between alkynyl enones, aldehydes and secondary amines is reported. With the aid of a benign indium catalyst, a range of highly substituted cyclopenta[ c ]furan derivatives can be obtained in a single‐step procedure. The formation of the stereodefined heterocyclic motifs takes place via in situ generation of enamines followed by two sequential cyclization steps.