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Palladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes
Author(s) -
Jiang Tuo,
Quan Xu,
Zhu Can,
Andersson Pher G.,
Bäckvall JanE.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600696
Subject(s) - palladium , oxidative phosphorylation , catalysis , ketone , chemistry , combinatorial chemistry , oxygen , surface modification , medicinal chemistry , organic chemistry , biochemistry
We report a palladium‐catalyzed oxidative functionalization of alkynes to generate α‐acetoxylated enones in one step. A range of functional groups are well‐tolerated in this reaction. Mechanistic studies, including the use of 18 O‐labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO.