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The Tricky Task of Nitrate/Nitrite Antiport
Author(s) -
Andrade Susana L. A.,
Einsle Oliver
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305421
Subject(s) - nitrite , nitrate , antiporter , chemistry , ion , biochemistry , membrane , biophysics , inorganic chemistry , biology , organic chemistry
Subtle differences : Two recent crystal structures have provided the first insight into nitrate/nitrite exchangers (example shown with bound nitrite), which are crucial to bacterial metabolism. A direct comparison of the structures reveals how the proteins can distinguish between their highly similar substrates and translate this into a conformational change to translocate ions across the membrane.