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Copper(II)‐Catalyzed Three‐Component Cascade Annulation of Diaryliodoniums, Nitriles, and Alkynes: A Regioselective Synthesis of Multiply Substituted Quinolines
Author(s) -
Wang Yong,
Chen Chao,
Peng Jing,
Li Ming
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300586
Subject(s) - annulation , regioselectivity , cascade , combinatorial chemistry , component (thermodynamics) , catalysis , chemistry , computer science , organic chemistry , physics , chromatography , thermodynamics
Three become one : Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a Cu II ‐catalyzed method. This cascade annulation is highly regioselective, step‐economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules.